Calcigard 1 to 1 125 mg 90 Tabs

The adult human body contains approximately 1,200 g ofcalcium, of which about 99% is present in the skeleton, and20-30 g of magnesium with about 60% located in bone. Theremaining 1% of total body calcium and 40% of total bodymagnesium are found in the soft tissues and play importantroles in such vital functions as nerve conduction, musclecontraction, energy metabolism, blood clotting, membranepermeability, and hormonal signaling. Blood calcium levelsare carefully maintained within very narrow limits by theinterplay of several hormones (1,25-dihydroxycholecalciferol,parathyroid hormone, calcitonin, estrogen,and testosterone) which control calcium absorption andexcretion, as well as bone metabolism. The intracellularlevels of magnesium are also very tightly regulated, sincetheir alterations can have profound effects on cardiac andskeletal muscle physiology.Intestinal calcium absorption ranges from 15 to 75% ofingested calcium. Adequate vitamin D status is necessary fornormal calcium absorption. Magnesium absorption isindependent of vitamin D status and ranges from 30 to 60%of ingested magnesium.Bone is constantly turning over, through a continuousprocess of formation and resorption. In children andadolescents, the rate of formation of bone mineralpredominates over the rate of resorption. In later life,resorption predominates over formation. Therefore, innormal aging, there is a gradual loss of bone.Osteoporosis afflicts a large proportion of the elderly indeveloped countries. Caucasian and Asian women typicallyhave low peak bone densities, and are therefore at thegreatest risk of developing osteoporosis. It is generallyaccepted that obtaining enough dietary calcium throughoutlife can significantly decrease the risk of developingosteoporosis. Among other factors, such as regular exercise,gender and race, calcium supplementation during childhoodand adolescence appears to be a prerequisite for maintainingadequate bone density later in life. But even elderlyosteoporotic patients can benefit significantly fromsupplementation with dietary calcium and magnesium.Calcigard One-to-One and Two-to-One provide highlybeneficial sources of both calcium and magnesium. They arewell absorbed and well tolerated. Calcium citrate, a highlybioavailable source of dietary calcium, is more completelyabsorbed than common calcium sources, such as calciumcarbonate. Calcium citrate is also better tolerated than mostforms of calcium. It does not give rise to intestinal gasproduction (due to release of carbon dioxide), bloating orconstipation as is often experienced with other calciumpreparations. Similarly, the magnesium amino acid chelatein Calcigard One-to-One and Two-to-One is well absorbedand generally well tolerated.Vitamin D (optional ingredient) is a key regulatory hormonefor calcium and bone metabolism. Adequate vitamin Dintake is important for ensuring normal calcium absorptionand maintaining proper calcium plasma levels. People livingin southern regions of the U.S. can derive significantamounts of vitamin D from sunlight dependent synthesis inthe skin during the summer, whereas people in the northernstates have to rely more on foods and supplements foradequate vitamin D status. This is why Calcigard formulasare available both with and without vitamin D.